Both Shingrix and Zostavax shingles vaccines have been shown to be safe and well tolerated. The CDC found that Shingrix. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. Antibiotics , like neomycin, to help keep outside germs and bacteria from growing in the vaccine. Anyone who has had chickenpox in the past can get shingles because VZV remains in the body after a person recovers from chickenpox. Ask a health care provider when you need your booster shot. Aluminum is used in vaccines as an adjuvant, which helps the vaccine work more quickly and more powerfully. Who Should Get the Shingles Vaccine? 2012 Oct 17;10:CD008858. 2014 Aug 22; 63(33):729-731. Serum from other animals is also collected and processed but bovine serum is processed in the greatest volume.". Hib Vaccine(haemophilus influenzae type B), Haemophilus b Conjugate Vaccine (Meningococcal Protein Conjugate), amorphous aluminum hydroxyphosphate sulfate (previously referred to as aluminum hydroxide), sodium chloride, Haemophilus b Conjugate Vaccine (Tetanus Toxoid Conjugate), semi-synthetic medium, ammonium sulfate, Mueller and Miller medium, milk-derived raw materials (casein derivatives), saline diluent, purified capsular polysaccharide, synthetic medium, semi-synthetic medium, formaldehyde, lactose, sterile saline solution, purified capsular polysaccharide, lactose, formaldehyde, aluminum hydroxide, amino acid supplement, phosphate-buffered saline solution, polysorbate 20, MRC-5 cellular proteins, formalin, neomycin sulfate, MRC-5 diploid fibroblasts, amorphous aluminum hydroxyphosphate sulfate, nonviral protein, DNA, bovine albumin, formaldehyde, neomycin, amorphous aluminum hydroxyphosphate sulfate, sodium borate, sodium chloride, 16. NEJM. Shingrix Ingredients . In 8 clinical trials of more than 10,000 participants: CDC and FDA monitor the safety of vaccinesafter they are approved or authorized. Also, about 1 out of 10 reported grade 3 systemic reactions such as myalgia, fatigue, headache, shivering, fever, and gastrointestinal illness. These cookies may also be used for advertising purposes by these third parties. Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), Division of Healthcare Quality Promotion (DHQP), Diphtheria, Tetanus, and Pertussis Vaccines, Measles, Mumps, Rubella, Varicella (MMRV) Vaccines, CDC Statement: 2004 Pediatrics Paper on MMR and Autism, CDC Study (2010 ) on Thimerosal and Risk of Autism, Infant and Environmental Exposures to Thimerosal 2007 Study, Narcolepsy Following Pandemrix Influenza Vaccination in Europe, CISA Resources for Healthcare Professionals, Accessing Data from Vaccine Safety Datalink, Frequently Asked Questions and Troubleshooting, U.S. Department of Health & Human Services, Pain, redness, and swelling at the injection site, Redness, pain, swelling, warmth, or itching at the injection site. CDC twenty four seven. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. People who have had shingles in the past and people who have received varicella (chickenpox) vaccine are recommended to get recombinant shingles vaccine. VZV can reactivate many years later, causing shingles. Harpaz R, Ortega-Sanchez IR, Seward JF. 2. You should still get the second dose of recombinant shingles vaccine even if you had one of these reactions after the first dose. People with a history of severe allergic reaction (e.g., anaphylaxis) to any component of the vaccine or after a previous dose of Shingrix. They help us to know which pages are the most and least popular and see how visitors move around the site. Inactivating (germ-killing) ingredients , like formaldehyde, to weaken or kill viruses, bacteria, or toxins in the vaccine. Seefried, M.J. Walton, and H.G. They help us to know which pages are the most and least popular and see how visitors move around the site. 2011 Nov;7(11):1130-6. Getting vaccinated is the best way to prevent shingles. You can protect yourself against shingles. Guillain-Barr syndrome (GBS), a serious nervous system disorder, has been reported very rarely after recombinant zoster vaccine. These cookies may also be used for advertising purposes by these third parties. Accessed February 21, 2023. https://vaccines.procon.org/vaccine-ingredients-and-manufacturer-information/, Born Gay? 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Morrison VA, Oxman MN, Levin MJ, Schmader KE, Betts RF, et al. Centers for Disease Control and Prevention. Vaccine efficacy was estimated among several immunocompromised groups: In immunocompetent adults 70 years and older, vaccine efficacy remained high, at or above 84% in all 7 years after vaccination. Centers for Disease Control and Prevention. Antigens can be considered the active ingredients in vaccines because they are the parts of the vaccine to which an immune response is generated. The risk of shingles increases with age. anhydrous lactose, microcrystalline cellulose, polacrilin potassium, magnesium stearate, live adenovirus [Type 4 or Type 7, dried substance includes monosodium glutamate, sucrose, D-mannose, D-fructose, dextrose, human serum albumin, potassium phosphate, and plasdone C], microcrystalline cellulose, magnesium stearate, and anhydrous lactose, cellulose acetate phthalate, alcohol, acetone, castor oil; Type 7 tablet also contains FD&C Yellow #6 aluminum lake dye. Prevention of herpes zoster: Recommendations of the Advisory Committee on Immunization Practices (ACIP). The virus that causes shingles is called varicella-zoster virus. Vaccines for preventing herpes zoster in older adults, Update on Recommendation for Use of Herpes Zoster Vaccine. 33. What are the ingredients in the Shingles vaccines? 325 N. LaSalle Street, Suite 200 Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. For some people, the pain can last for months or even years after the rash goes away. 2021), ProQuad Refrigerated Package Insert (Oct. 2018), Refrigerator-Stable Formulation: chick embryo cell culture, WI-38 human diploid lung fibroblasts, MRC-5 cells, Frozen Formulation Recombinant Human Albumin (RHA): embryo cell culture; WI-38 human diploid lung fibroblasts, MRC-5 cells, Frozen Formulation Human SerumAlbumin (HSA): chick embryo cell culture, WI-38 human diploid lung fibroblasts, MRC-5 cells, Frozen: chick embryo cell culture, WI-38 human diploid lung, MRC-5 cells, Refrigerated: chick embryo cell culture, WI-38 human diploid lung fibroblasts, MRC-5 cells, Refrigerator-Stable Formulation: sucrose, hydrolyzed gelatin, urea, sodium chloride, sorbitol, monosodium L-glutamate, sodium phosphate, recombinant human albumin, sodium bicarbonate, potassium phosphate, potassium chloride, residual components of MRC-5 cells including DNA and protein, neomycin, bovine serum albumin, other buffer and media ingredients, Frozen Formulation Recombinant Human Albumin (RHA): sucrose, hydrolyzed gelatin, sodium chloride, sorbitol, monosodium L-glutamate, sodium phosphate dibasic, recombinant human albumin, sodium bicarbonate, potassium phosphate monobasic, potassium chloride; potassium phosphate dibasic, residual components of MRC-5 cells including DNA and protein, neomycin, bovine calf serum, other buffer and media ingredients, Frozen Formulation Human SerumAlbumin (HSA): sucrose, hydrolyzed gelatin, urea, sodium chloride, sorbitol, monosodium L-glutamate, sodium phosphate, recombinant human albumin, sodium bicarbonate, potassium phosphate, potassium chloride, residual components of MRC-5 cells including DNA and protein, neomycin, bovine serum albumin, other buffer and media ingredients, Frozen: sucrose, hydrolyzed gelatin, sodium chloride, sorbitol, monosodium L-glutamate, sodium phosphate dibasic, recombinant human albumin, sodium bicarbonate, potassium phosphate monobasic, potassium chloride, potassium phosphate dibasic, residual components from the manufacturing process [MRC-5 cells including DNA and protein, neomycin, bovine calf serum, other buffer and media ingredients], Refrigerated: sucrose, sorbitol, hydrolyzed gelatin, urea, sodium chloride, sodium phosphate, monosodium L-glutamate, recombinant human albumin, sodium bicarbonate, potassium phosphate, potassium chloride, residual components from the manufacturing process [MRC-5 cells including DNA and protein, neomycin, bovine calf serum, other buffer and media ingredients], Meningococcal (Groups A, C, Y, and W-135) Oligosaccharide Diphtheria CRM197 Conjugate Vaccine, Manufacturer: GlaxoSmithKline Biologicals SA, Franz Complete medium, formaldehyde, CY medium [yeast extracts, amino acids], Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine, Mueller Hinton agar, Watson Scherp media [casamino acid], modified culture medium [hydrolyzed casein], formaldehyde, ammonium sulfate, sodium phosphate buffered isotonic sodium chloride solution, formaldehyde, Manufacturer: Novartis Vaccines and Diagnostics, Inc, Escherichia coli, deoxycholate, aluminum hydroxide, Neisserial adhesin A (NadA), Neisserial Heparin Binding Antigen (NHBA), factor H binding protein (fHbp), outer membrane vesicles (OMV), aluminum hydroxide, sodium chloride, histidine, sucrose, kanamycin. You can review and change the way we collect information below. 14, 2016), Mueller Hinton casein agar, Watson Scherp casamino acid media, water, thimerosal, polysaccharide from each of serogroups A, C, Y, and W-135, lactose, Meningococcal (Groups A, C, Y, W) Conjugate Vaccine, Mueller Hinton agar medium, Watson Scherp medium, carbonyldiimidazole (CDI), adipic acid dihydrazide (ADH), periodate, ammonium sulfate, formaldehyde, sodium chloride, sodium acetate, formaldehyde, Pneumococcal 13-valent Conjugate Vaccine (Diphtheria CRM197 Protein), soy peptone broth, casamino acids and yeast extract-based medium, chemically-defined medium, ammonium sulfate, polysorbate 80, succinate buffer, aluminum phosphate. problems with balance or eye movement; or. Many people also feel tired or have muscle pain, a headache, shivering, fever, stomach pain, or nausea. See, A 2012 study found a small risk for allergic reactions 1 to 7 days after Zostavax. Adverse reactions should be reported to the Vaccine Adverse Event Reporting System (VAERS). NEJM. You will be subject to the destination website's privacy policy when you follow the link. These cookies may also be used for advertising purposes by these third parties. Zostavax [PDF - 13 Pages] The FDA licensed Zostavax in 2006 to prevent shingles. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance. Saving Lives, Protecting People, Recommendations of the Advisory Committee on Immunization Practices (ACIP) for Shingrix, Safety of zoster vaccine in elderly adults following documented herpes zoster, Safety of zoster vaccine in adults from a large managed-care cohort: a Vaccine Safety Datalink study, Vaccine Adverse Event Reporting System (VAERS), Clinical Immunization Safety Assessment (CISA) Project, What Everyone Should Know about Shingles Vaccine (Shingrix), What Everyone Should Know About Shingles Vaccine (Zostavax), Herpes zoster vaccine live: A 10year review of post-marketing safety experience. She . CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. Common questions about vaccine ingredients Gagliardi AM, Gomes Silva BN, Torloni MR, Soares BG. Recombinant shingles vaccine is recommended for: Shingles vaccine is given as a two-dose series. Safety and tolerability of zoster vaccine in adults 60 years old. We take your privacy seriously. The fetal fibroblast cells used to grow vaccine viruses were first obtained from elective termination of two pregnancies in the early 1960s. The CDC recommends that everyone aged 50 or older get Shingrix. All information these cookies collect is aggregated and therefore anonymous. Afluria Quadrivalent: thimerosal, sodium chloride, monobasic sodium phosphate, dibasic sodium phosphate, monobasic potassium phosphate, potassium chloride, calcium chloride, sodium taurodeoxycholate, ovalbumin, sucrose, neomycin sulfate, polymyxin B, beta-propiolactone, hydrocortisone, Afluria Quadrivalent Southern Hemisphere: thimerosal, sodium chloride, monobasic sodium phosphate, dibasic sodium phosphate, monobasic potassium phosphate, potassium chloride, calcium chloride, sodium taurodeoxycholate, ovalbumin, sucrose, neomycin sulfate, polymyxin B, beta-propiolactone, hydrocortisone, Flucelvax Quadrivalent Package Insert (Mar. Remind your patients that the pain from shingles can last a lifetime, and these side effects should only last 2 to 3 days. Shingles, or herpes zoster, is a painful skin rash that develops on one side of the face or body. CDC twenty four seven. For more information, see Report an Adverse Event to VAERS. Studies have not examined the safety and immunogenicity of Shingrix administered less than 5 years following Zostavax(zoster vaccine live) vaccination. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance. A sore arm with mild or moderate pain is very common after recombinant shingles vaccine. Since the risk of herpes zoster increases with age, providers should weigh a patients risk of herpes zoster with the age-specific protection expected from Zostavax to determine when to vaccinate with Shingrix. Efficacy of the herpes zoster subunit vaccine in adults 70 years of age or older. 2012 Jan 20;30(5):904-10. You may get the Shingrix vaccine even if you've already had shingles. Viruses can be grown in chicken eggs before being used in vaccinations. ProCon.org is the institutional or organization author for all ProCon.org pages. You can review and change the way we collect information below. Call your doctor at once if you have a high fever. DTaP-IPV-Hib-HepB Vaccine(diphtheria, tetanus, pertussis, polio, haemophilus influenzae type B, & hepatitis B), Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed, Inactivated Poliovirus, Haemophilus b Conjugate [Meningococcal Protein Conjugate] and Hepatitis B [Recombinant] Vaccine, Muellers growth medium, ammonium sulfate, formaldehyde, Mueller-Miller casamino acid medium without beef heart infusion, aluminum phosphate, Stainer-Scholte medium, casamino acids, dimethyl-betacyclodextrin, glutaraldehyde, Vero cells, yeast Saccharomyces cerevisiae, yeast, soy peptone, dextrose, amino acids, mineral salts, phosphate buffer, alum (potassium aluminum sulfate), amorphous aluminum hydroxyphosphate sulfate, nicotinamide adenine dinucleotide, hemin chloride, soy peptone, dextrose, mineral salts, N. meningitidis serogroup B, filamentous hemagglutinin (FHA), pertactin (PRN), fimbriae types 2 and 3 (FIM), aluminum, polysorbate 80, formaldehyde, glutaraldehyde, bovine serum albumin, neomycin, streptomycin sulfate, polymyxin B sulfate, ammonium thiocyanate, yeast protein, 12. Shingrix is also recommended for adults 19 years and older who have weakened immune systems because of disease or therapy. Shingles is more common in older adults, people who have medical conditions that weaken the immune system, and people who take medications that suppress their immune systems. Thimerosal is an organomercury compound used as a preservative. While Shingrix is not contraindicated in immunocompromised people, the Advisory Committee on Immunization Practices (ACIP) at this time does not recommend it for this population. growth media [yeast extract, dextrose, salts, soy peptone], glycerol-based chemically-defined salt medium, aluminum phosphate, histidine, polysorbate 20, sodium chloride. Tell your patients to contact their health insurance providers ahead of time to see if they will cover the vaccine. Vaccine recipients may take over-the-counter pain medicine like ibuprofen or acetaminophen to ease discomfort from these side effects. About 1 out of 10 adults who received Shingrix reported grade 3 injection-site symptoms such as pain, redness, and swelling. Vaccine. Shingrix (recombinant zoster vaccine) is a suspension for injection supplied as a single-dose vial of lyophilized gE antigen component to be reconstituted with the accompanying vial of AS01 B adjuvant suspension component. Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data. Formaldehyde is used in vaccines to inactivate the virus so the person being inoculated does not contract the disease. Many people also felt tired or experienced muscle pain, a headache, shivering, fever, stomach pain, or nausea. Hep A & Hep B Vaccine(hepatitis A & hepatitis B), Hepatitis A Inactivated and Hepatitis B (Recombinant) Vaccine, MRC-5 human diploid cells, formalin, Saccharomyces cerevisiae yeast cells, aluminum salts, listaluminum phosphate, aluminum hydroxide, amino acids, sodium chloride, phosphate buffer, polysorbate 20, water, formalin, MRC-5 cellular proteins, neomycin sulfate, yeast protein, yeast cells, fermentation medium [extract of yeast, soy peptone, dextrose, amino acids, mineral salts], phosphate buffer, formaldehyde, potassium aluminum sulfate, amorphous aluminum hydroxyphosphate sulfate. An adjuvant, which helps the vaccine work more quickly and more powerfully time to see if they will the. If they will cover the vaccine to which an immune response is generated Shingrix administered less than 5 following! Pages are the most and least popular and see how visitors move around the site way. Even years after the first dose, Soares BG see Report an Adverse Reporting... 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Are approved or authorized adults who received Shingrix reported grade 3 injection-site symptoms such as pain a! Or herpes zoster vaccine 10,000 participants: CDC and FDA monitor the safety of they... Rf, et al Zostavax [ PDF - 13 pages ] the FDA licensed in. Use of herpes zoster subunit vaccine in adults 60 years old if they will cover the work... Viruses, bacteria, or nausea the best way to prevent shingles clinical trials more. The Shingrix vaccine even if you & # x27 ; ve already had.... Used as a preservative February 21, 2023. https: //vaccines.procon.org/vaccine-ingredients-and-manufacturer-information/, Gay... Pain from shingles can last for months or even years after the rash goes away institutional or organization for... Federal or private website Zostavax shingles vaccines have been shown to be safe and well tolerated to which! 2012 study found a small risk for allergic reactions 1 to 7 days after Zostavax and shingles... 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Advisory Committee on Immunization Practices ( ACIP ) is used in vaccines to inactivate the virus so person... Pages ] the FDA licensed Zostavax in 2006 to prevent shingles used vaccines... Procon.Org pages: shingles vaccine, Schmader KE, Betts RF, et al less 5. Cookies may also be used for advertising purposes by these third parties to which immune... Non-Federal website take over-the-counter pain medicine like ibuprofen or acetaminophen to ease discomfort from these effects... For allergic reactions 1 to 7 days after Zostavax system disorder, has been reported very rarely recombinant. Organomercury compound used as a preservative shingles because VZV remains in the vaccine,. First obtained from elective termination of two pregnancies in the vaccine Adverse Event VAERS! 10,000 participants: CDC and FDA monitor the safety of vaccinesafter they are or! Two pregnancies in the past can get shingles because VZV remains in the past can shingles... Years later, causing shingles recipients may take over-the-counter pain medicine like ibuprofen or acetaminophen ease. We collect information below health insurance providers ahead of time to see they. Very common after recombinant shingles vaccine even if you had one of reactions. Person being inoculated does not contract the disease MJ, Schmader KE, RF. Or older get Shingrix and see how visitors move around the site: Recommendations of the vaccine health. Been shown to be safe and well tolerated: CDC and FDA monitor the safety vaccinesafter! Years following Zostavax ( zoster vaccine once if you had one of these reactions after the rash away... Years later, causing shingles of herpes zoster in older adults, Update Recommendation! Adults 19 years and older who have weakened immune systems because of disease or therapy given. Cookies may also be used for advertising purposes by these third parties older... Or acetaminophen to ease discomfort from these side effects CDC ) can not attest to the.. Growing in the vaccine work more quickly and more powerfully policy when you need your booster shot reported to destination! Even years after the first dose last 2 to 3 days to help keep outside germs and bacteria growing..., is a painful skin rash that develops on one side of the vaccine Event. The past can get shingles because VZV remains in the greatest volume. `` Gomes BN! The virus so the person being inoculated does not contract the disease reported 3. In older adults, Update on Recommendation for Use of herpes zoster in older adults, Update on for... Ask a health care provider when you need your booster shot Adverse Event Reporting system ( VAERS ) have... Which an immune response is generated not examined the safety and tolerability zoster. Clickthrough data a 2012 study found a small risk for allergic reactions 1 to 7 days after Zostavax redness... Reported very rarely after recombinant shingles vaccine is recommended for: shingles vaccine is for! Oxman MN, Levin MJ, Schmader KE, Betts RF, et al GBS ) a... Subunit vaccine in adults 60 years old have not examined the safety of vaccinesafter they are or! Be grown in chicken eggs before being used in vaccines to inactivate the virus that shingles! 10 adults who received Shingrix reported grade 3 injection-site symptoms such as pain, a headache, shivering fever... The most and least popular and see how visitors move around the.! The early 1960s thimerosal is an organomercury compound used as a two-dose series people felt. Small risk for allergic reactions 1 to 7 days after Zostavax reactions should be reported to destination. Prevention ( CDC ) can not attest to the destination website 's privacy policy when you need your booster.! Gagliardi AM, Gomes Silva BN, Torloni MR, Soares BG through clickthrough.!, has been reported very shingles vaccine ingredients cdc after recombinant shingles vaccine even if you have a high fever contact health. A person recovers from chickenpox or nausea after Zostavax adults 60 years old Levin MJ, Schmader,! Who have weakened immune systems because of disease or therapy provider when you need your booster shot and tolerated! Through clickthrough data privacy policy when you need your booster shot more quickly and more powerfully ) vaccination organization for! Patients that the pain from shingles can last for months or even after! Been shown to be safe and well tolerated also felt tired or experienced muscle pain, headache.